Extracellular histones exert a differential cytotoxic and antiangiogenic effect in progenitor and mature endothelial cells.

MENA HA; SCHATTNER M; NEGROTTO S

Congreso; Gordon Research Conferences - Angiogenesis; 2015

Background: Extracellular histones are highly augmented not only in infection but also in sites of neovessel formation, like peritumoral and regeneration tissues. Their cytotoxic effect on endothelial cells has been extensively studied. Aims: To further analyze histone cytotoxicity in endothelial cells and whether histones affect endothelial angiogenic functions.Methods: Endothelial cells from micro (HMEC1) and macrovascular (HUVEC) beds and late outgrowth endothelial colony forming cells (ECFC) were treated with individual human recombinant histones. Data are shown as % of inhibition, p