Effect of histones on angiogenic responses of progenitor and mature endothelial cells

MENA HA; SCHATTNER M; NEGROTTO S

Congreso; Annual Meeting of the SSC ISTH Congress; 2014

ISTH

Histones are major components of neutrophil extracellular traps which are released by inflammatory cells at sites of infection, thrombosis, cancer and tissue regeneration. Considering that vascular repair and formation of new vessel from preexisting ones (angiogenesis) and de novo (vasculogenesis) are key events in these clinical situations, we aimed to analyze the effect of histones on the angiogenic activity of endothelial cells involved in vasculogenesis such as late growth endothelial progenitor cells (EPC) and angiogenesis including human umbilical vein endothelial cells (HUVEC) and human dermal microvascular endothelial cells (HMEC). Data are shown as % of inhibition (% inh), n=4-6, p