Modulation of Systemic immunity by all-trans retinoic acid administration (ATRA) in a murine model of lipopolysaccharide-induced immunosuppression

MARTIRE-GRECO D; RODRIGUEZ-RODRIGUES N; LANDONI V.I; MEISS R; CHIARELLA P; REARTE B.; SCHIERLOH P.; ISTURIZ M.A; FERNANDEZ G.C.

Mar del Plata

Congreso; LIX REUNIÓN CIENTÍFICA ANUAL Sociedad Argentina de Investigación Clínica. LXII REUNIÓN ANUAL Sociedad Argentina de Inmunología; 2014

SAIC/SAI

Efforts to recover the immune functions of patients with post-sepsis immunosuppression will be a breakthrough in the management of this condition. All-trans retinoic acid (ATRA) is a derivative of vitamin A with immunomodulatory properties that have effects on different immune cell populations. Our aim was to study different effects of ATRA on the systemic immune response in immunosuppressed mice (IS) by chronic inoculation of LPS and concomitant ATRA administration. For this purpose we apply daily increasing doses of LPS i.p. (5-100 ug/day/mouse) for 20 days and administered ATRA orally or i.p. (500 ug/day/mouse) (IS+ATRA group) or vaseline (vehicle) (IS group). Oral administration of ATRA to IS mice was able to increase the removal of bacteria in the peritoneal cavity after 3 h of bacterial inoculation (remaining colony formation units in peritoneal lavages: IS = 82±13, IS+ATRA = 38±9, p