The interaction of dendritic cells and Foot-and-Mouth Disease Virus activates ERK1/2 pathway responsible of MHC class I presentation and apoptosis

C. LANGELLOTTI; G. CESAR; E. PEREYRA; V. GNAZZO; V QUATTROCCHI; M. GAMMELLA; P ZAMORANO; M. VERMEULEN

Filadelfia

Conferencia; 8th vaccine & ISV congress 2014; 2014

Elseiver

Foot-and-mouth disease (FMD) is a highly contagious viral disease of clovenhoofedanimals. FMD is caused by foot-and-mouth disease virus (FMDV). It?sthe most economically important disease of livestock worldwide, due to theinternational restrictions imposes for the marketing of meal. Vaccines currently used against the FMD contain the inactivated form of virus (iFMDV). It?s known that infection induces an immune response quite different from vaccination which does not induce a rapid immunity or durable memory. Previously, we demonstrated that infection and vaccination affect differentiallythe recruitment of splenic dendritic cells (DCs) subsets that culminated with a opposite modulation of adaptive immune response. Here we investigated the intracellular pathways activated by iFMDV and FMDV on DCs, that could explain the functional differences observed between both particles.