IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
VITAMIN A LEVELS INFLUENCE SHIGA TOXIN 2 SUSCEPTIBILITY IN BALB/C MICE
Autor/es:
CABRERA G; FERNANDEZ BRANDO R J; MEJÍAS M P; ABREY RECALDE M J; PANEK C A; PINTO A; GOLDSTEIN J; PALERMO M S
Lugar:
Los Cocos
Reunión:
Congreso; . LXI Reunión Científica Anual de la Sociedad Argentina de Inmunología; 2013
Resumen:
Shiga-toxin (Stx) producing Escherichia coli strains can cause a broad spectrum of human diseases, including the life-threatening hemolytic uremic syndrome. Since vitamin A (VA) influences a wide variety of processes in the intestine and the immune system, the aim of this study was to analyze whether VA levels influenced Stx2- susceptibility in BALB/c mice. A VA-deficient (VA-D) diet was used to generate VA-D mice, as previously described (Smith, Levy et al. 1987). After the intravenous (i.v.) inoculation of a lethal dose100 (LD100) of Stx2 (4-5 ng), VA-D mice showed a reduced mortality as compared to Control mice, (% mortality, n): (A) Control mice 95%, 20; (B) VA-D mice: 5%, 20. p