IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of B cells in tuberculous pleurisy
Autor/es:
SASIAIN MARÍA DEL CARMEN
Lugar:
Buenos Aires
Reunión:
Workshop; 1st German-Argentinean Workshop on ?Pathogen Invasion and Immune Evasion; 2012
Institución organizadora:
Fundación Crimson
Resumen:
Although it is well known the role of T cell-mediated immunity in the containment of M. tuberculosis and, in spite of the growing clinical and experimental evidences for an active role of B cells in intracellular granulomatous infections, the role for B lymphocytes in host defense against M. tuberculosis has not yet decisively defined. Tuberculous pleurisy is a well-known example of local T helper 1-mediated DTH reaction in which CD4+ T cells are the most prominent effector population that makes tuberculous pleurisy a relevant model for the study of T-B cells cross-talk at the site of infection. We found that B cells from pleural fluid (PF) are activated and in response to ex vivo stimulation with M .tuberculosis, B cells from PF produced IL-10 being this process dependent on the presence of non-B pleural lymphocytes (PF-CD19neg cells). Besides, CD19+ cells regulate IFN-γ production from NK and T cells through the involvement of endogenously secreted IL-10. In addition, within the PF, the higher the ratio of IFN-γ/IL10 amounts the lower the frequencies of B cells. So, our results identify a new negative feedback loop taking place at the inflammatory site.