High anti-factor v (AFV) activity and no-spontaneous bleeding: a case report

GROSSO SH; INGRATTI M; ALFONSO G; SÁNCHEZ LUCEROS A; MESCHENGIESER SS; BLANCO AN; LAZZARI MA

Kyoto

Congreso; XXIII Congress of the International Society on Thrombosis and Haemostasis; 2011

International Society on Thrombosis and Haemostasis

aFV is a rare disorder. Alloantibodies or Autoantibodies are described. Patients can be asymptomatic or have mild to fatal haemorrhagic complications, without correlation with FV levels. The disappearance of the inhibitor can be spontaneous or not, requiring therapy according to the symptoms. We report the case of a 72 year old man, diabetic type II, requiring a total knee replacement who presented in a pre-surgery evaluation a very prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), both of which were not corrected by the addition of pool normal plasma (1:1 mixture). He had neither family nor personal history of bleeding, including prostatectomy. Initially, no conclusive results were observed: prolonged PT (14%; N 100%; P:N 17%), APTT (118 s; N 43 s; P:N 115 s) and dRVVT not corrected by normal plasma, negative phospholipids neutralization tests, no time dependent effect; low FII, V, VIII, IX and X levels (