IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ASSISTED REPRODUCTION TECHNOLOGIES FAILURE AND ACQUIRED THROMBOPHILIA: EXPERIENCE OF A SINGLE SPECIALIZED ARGENTINIAN CENTER.
Autor/es:
BEGUE G; SÁNCHEZ LUCEROS A; MESCHENGIESER SS; GROSSO SH; BLANCO AN; ALBERTO MF; LAZZARI MA
Lugar:
Liverpool
Reunión:
Congreso; 58th Annual Meeting of the Scientific and Standardization Committee of the ISTH; 2012
Institución organizadora:
International Society on Thrombosis and Haemostasis
Resumen:
Objectives: Thrombophilia has been lately associated with recurrent miscarriage and other pregnancy adverse outcomes. Unsuccessful implantation (UI) and placentation have been considered as potential explanations for the high failure rate of assisted reproduction technologies (ART). However, there is still conflicting evidence about the causative link between acquired thrombophilia (AT), UI and ART outcome.Thrombophilia has been lately associated with recurrent miscarriage and other pregnancy adverse outcomes. Unsuccessful implantation (UI) and placentation have been considered as potential explanations for the high failure rate of assisted reproduction technologies (ART). However, there is still conflicting evidence about the causative link between acquired thrombophilia (AT), UI and ART outcome. Methods: We have evaluated a prospective cohort of 81 consecutive infertile women (January-December 2011), from a single specialized Hemostasis and Thrombosis Department in Argentina, to determine the relationship between ART and AT. Patients were included after at least one high complexity ART failure, in spite of good embryos quality. Lupus anticoagulant (LA), anticardiolipin antibodies (ACA), euglobulin clot lysis time (ECLT) with venous occlusion response were evaluated. LA was defined according to the SSC-ISTH criteria. ACA were detected using a commercial kit (ELISA INOVA ACA III).We have evaluated a prospective cohort of 81 consecutive infertile women (January-December 2011), from a single specialized Hemostasis and Thrombosis Department in Argentina, to determine the relationship between ART and AT. Patients were included after at least one high complexity ART failure, in spite of good embryos quality. Lupus anticoagulant (LA), anticardiolipin antibodies (ACA), euglobulin clot lysis time (ECLT) with venous occlusion response were evaluated. LA was defined according to the SSC-ISTH criteria. ACA were detected using a commercial kit (ELISA INOVA ACA III). Results: The average age of the patients was 38 years old (29–49). 58 (71%) patients had primary infertility (never having achieved a positive Human Chorionic Gonadotropin blood test). Overall, 75.3% of women had other plausible cause of infertility (endocrinologic diseases 29.6%, endometriosis 22%, Fallopian tube obstruction 21%, ginecologic resection surgery 12%, smoking 9.8%, poor ovarian reserve 6%). 51 (62%) of the patients had normal test results. LA was identified in 15 patients, but its persistence could only be demonstrated in 9 cases. All of 6 cases expressing ACA had low antibodies title, only two demonstrated persistent positivity. ECLT was prolonged in 9 cases. No significant differences were found between primary and secondary infertility.The average age of the patients was 38 years old (29–49). 58 (71%) patients had primary infertility (never having achieved a positive Human Chorionic Gonadotropin blood test). Overall, 75.3% of women had other plausible cause of infertility (endocrinologic diseases 29.6%, endometriosis 22%, Fallopian tube obstruction 21%, ginecologic resection surgery 12%, smoking 9.8%, poor ovarian reserve 6%). 51 (62%) of the patients had normal test results. LA was identified in 15 patients, but its persistence could only be demonstrated in 9 cases. All of 6 cases expressing ACA had low antibodies title, only two demonstrated persistent positivity. ECLT was prolonged in 9 cases. No significant differences were found between primary and secondary infertility. Conclusion: LA was detected in 11% of the patients studied. Although we do not have a control group, LA seems to be more prevalent in this group than in general population. However, we can not confirm its causative association. YOUNG TRAVEL INVESTIGATOR AWARD. http://www.ssc2012.org/Awards_and_Grants_2012.pdf  LA was detected in 11% of the patients studied. Although we do not have a control group, LA seems to be more prevalent in this group than in general population. However, we can not confirm its causative association. YOUNG TRAVEL INVESTIGATOR AWARD. http://www.ssc2012.org/Awards_and_Grants_2012.pdf