IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
capítulos de libros
Título:
Increases in superantigen-specific Treg cells during MMTV infection are TLR4-dependent
Autor/es:
CABRERA G; BURZIN D.; COURREGES MB; MUNDINIANO J; CAMICIA G; LORENZO D; MAGLIOCO AF; ROSS SR; NEPOMNASCHY I; PIAZZON I
Libro:
Immunology 2007
Editorial:
Monduzzi Editore
Referencias:
Lugar: Bologna, Italia; Año: 2007; p. 523 - 528
Resumen:
Increases in superantigen-specific Treg cells during MMTV infection are TLR4-dependent.
Mouse mammary tumor virus (MMTV) is a retrovirus transmitted during lactation that
causes mammary tumors. It is well known that MMTV employs a superantigen (Sag)
codified in its genome to exploit the host immune system and establish infection. It had
been described that some pathogens induce regulatory cells in order to subvert the
immune system. Since we have previously shown that some of the events that take place
during MMTV infection are dependent on Toll-Like Receptor 4 (TLR4), in the present
study we have investigated the induction of regulatory T cells during MMTV infection
and the involvement of TLR4 in this process. Results obtained show that MMTV is able
to induce an early increase in Sag-specific regulatory T cells in a TLR4 dependent
manner.