Prevalence of Early B-Cell Factor 1 Gene rs4704963 Single Nucleotide Polymorphism (T>C) in a Population of Type 2 Diabetic Patients with Obesity

MARIO B PRINCIPATO; J BRAGAGNOLO; JUSTO CARBAJALES; ALEJANDRA DUARTE; VONWULFFEN MA; CASTILLA ROCÍO; ORTENSI G; ACUNZO RS

Revista Argentina de Cardiología

Sociedad Argentina de Cardiología

Año: 2018

1850-3748

Background: Previous studies established that in a population with exacerbation of type 2 diabetes with obesity (DBT+Ob)suffering from stress, the prevalence of early B-Cell Factor 1 (EBF1) gene rs4704963 single nucleotide polymorphism (SNP)(T>C) is 16.5%.Objectives: The aim of this study was to determine the prevalence of this SNP in patients with DBT+Ob attending HospitalRamos Mejía of the Autonomous City of Buenos Aires and to ascertain whether this polymorphism is associated with stressor acute coronary events.Methods: An observational, prospective study on the prevalence of rs4704963 SNP was performed in 53 patients with DBT+Oband body mass index between 28 and 41, seen in Hospital Ramos Mejía for a period of 15 months. Each patient was evaluatedwith a stressful life events scale and a perceived stress scale.The chi-square test and odds ratio (OR) were used for statistical analysis.Results: A total of 53 patients were included in the study. Mean population age was 60.2±9.77 years and 47.2% were men.Among these patients, 8 (15.1%) presented SNP and all were heterozygous. Fifteen patients (28.3%) had acute ischemicsyndrome (AIS), and among these, only one (6.6%) had SNP. No statistically significant relationship was found between thepresence of SNP and AIS (p=0.282). Fourteen patients (26.4%) presented moderate or severe chronic stress, and there wasno relationship between this finding and the presence of SNP (p=0.979).Conclusions: The prevalence of EBF1 gene rs4704963 SNP (T>C) in the DBT+Ob population was 15.1%. No statisticallysignificant association was found between SNP and stress or AIS.