IMEX 05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Role of the polymorphonuclear leukocytes in the pathophysiology of the typical Hemolytic Uremic Syndrome
Autor/es:
EXENI R.; FERNANDEZ G.C.; PALERMO M.S.
Revista:
The Scientific World Journal
Editorial:
The Scientific World
Referencias:
Año: 2007 vol. 7 p. 1155 - 1164
ISSN:
1537-744X
Resumen:
Thrombotic microangiopathy and acute renal failure are cardinal features of postdiarrheal hemolytic uremic syndrome (HUS). These conditions are related to endothelial and epithelial cell damage induced by Shiga toxin (Stx), through an interaction with its globotriaosylceramide (Gb3) receptor. Although, Stx is the main pathogenic factor and necessary for HUS development, clinical and experimental evidence suggest that the inflammatory response is able to potentiate Stx toxicity. Lipopolysaccharides (LPS) and neutrophils (PMN) represent two central components of inflammation during a gramnegative infection. In this regard, patients with high peripheral PMN counts at presentation have a poor prognosis. In the present review, we discuss the contribution of experimental models and patients studies in an attempt to elucidate the pathogenic mechanisms of HUS.
