IMEX 05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Investigation of residual hepatitis C virus in presumed recovered subjects
Autor/es:
FUJIWARA K; ALLISON RD; WANG RI; BARE P; MATSUURA K; SCHECHTERLY C; MURTHY K; MARINCOLA F; ALTER HJ
Revista:
HEPATOLOGY (BALTIMORE, MD.)
Editorial:
JOHN WILEY & SONS INC
Referencias:
Lugar: New York; Año: 2013 p. 483 - 491
ISSN:
0270-9139
Resumen:
Recent studies have found hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells (PBMCs) of the majority of presumed recovered subjects. We investigated this unexpected finding using samples from patients whose HCV RNA and anti-HCV status had been serially confirmed. HCV RNA was detected in PBMCs from 66/67 chronic HCV carriers. Subpopulation analysis revealed that the viral load (log copies/10(6) cells) in B cells (4.14 ± 0.71) was higher than in total PBMCs (3.62 ± 0.71, p
