IMEX   05356
INSTITUTO DE MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
artículos
Título:
Increases in IgA+ B cells in Peyers patches during milk-borne mouse mammary tumor virus infection are influenced by Toll-like receptor 4 and are completely dependent on the superantigen response
Autor/es:
CABRERA G; VERCELLI CLAUDIA ; DALIA BURZYN; BADANO N; ANDREA MAGLIOCO; COSTA H; MUNDIÑANO J; CAMICIA G; NEPOMNASCHY I; PIAZZON I
Revista:
JOURNAL OF GENERAL VIROLOGY
Editorial:
SOC GENERAL MICROBIOLOGY
Referencias:
Año: 2010 p. 2814 - 2820
ISSN:
0022-1317
Resumen:
Mouse mammary tumor virus (MMTV) is a milk-borne betaretrovirus that has developed strategies
to exploit and subvert the host immune system. Although mammary glands are the final target of
infection, Peyers patches (PP) are the entry site of the virus. Herein, we show that the infection
induces increases in the number of PP IgA+ B cells and higher expression of the a circular
transcript, which is a specific marker of the switch to IgA. In addition, IgA+ B-cell increases
correlated with higher levels of cytokines related to IgA class switching, such as interleukin (IL)-5
and IL-6. Of interest, the increases in IgA+ B cells were lower in Toll-like receptor 4-deficient
mice and were completely dependent on the presence of superantigen-reactive T cells. Our
results point to a novel mechanism involved in MMTV infection and suggest that IgA+ B cells may
play an important role in carrying the virus to the mammary glands.+ B cells and higher expression of the a circular
transcript, which is a specific marker of the switch to IgA. In addition, IgA+ B-cell increases
correlated with higher levels of cytokines related to IgA class switching, such as interleukin (IL)-5
and IL-6. Of interest, the increases in IgA+ B cells were lower in Toll-like receptor 4-deficient
mice and were completely dependent on the presence of superantigen-reactive T cells. Our
results point to a novel mechanism involved in MMTV infection and suggest that IgA+ B cells may
play an important role in carrying the virus to the mammary glands.+ B-cell increases
correlated with higher levels of cytokines related to IgA class switching, such as interleukin (IL)-5
and IL-6. Of interest, the increases in IgA+ B cells were lower in Toll-like receptor 4-deficient
mice and were completely dependent on the presence of superantigen-reactive T cells. Our
results point to a novel mechanism involved in MMTV infection and suggest that IgA+ B cells may
play an important role in carrying the virus to the mammary glands.+ B cells were lower in Toll-like receptor 4-deficient
mice and were completely dependent on the presence of superantigen-reactive T cells. Our
results point to a novel mechanism involved in MMTV infection and suggest that IgA+ B cells may
play an important role in carrying the virus to the mammary glands.+ B cells may
play an important role in carrying the virus to the mammary glands.