ININFA   02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Modafinil attenuates methamphetamine acute toxic effects in mice.
Autor/es:
M. RAINERI; I. TARAVINI; V. PESKIN; F. J. URBANO; S.I. WIKINSKI; V. BISAGNO
Lugar:
Huerta Grande, Cordoba
Reunión:
Congreso; II REUNION CONJUNTA DE NEUROCIENCIAS; 2010
Institución organizadora:
SAN/TAN
Resumen:
Long term Methamphetamine (METH) exposure has been shown to produce  deletereous effects on brain function. Recent clinical data have supported the use off-label of Modafinil (MOD) for the treatment of  psychostimulant addiction. Here we evaluate the potential neuroprotective role of MOD on METH neurotoxic effects in mice treated either with a single injection (2 or 7 mg/kg) or with a binge dosing  protocol of METH (3x 7mg/Kg, ip. 3 h apart) co-administrated with MOD  (2x 180 or 90 mg/Kg, 1 h before first and third METH injection); control groups received vehicles. As expected, acute METH administration induced hyperlocomotion and increased continuous sniffing compared to MOD and control group; MOD induced a dose dependent increase in locomotor activity without altering stereotyped  behavior; MOD+METH group exhibited locomotor activity values similar  to the saline group but showed enhanced stereotyped behavior. Six days after METH binge, reduced distance traveled was observed in METH treated animals, except for the group pretreated with MOD 90 mg/kg. Striatal dopamine content (measured by HPLC) and TH immunoreactivity decreased in METH group while MOD+METH showed similar values compared to the saline group. Our results suggest a possible protective role of MOD against METH acute toxicity. Supported by: PICT 2007-1009 (F.U.), PICT 31953, UBACyT M013 (S.W.)