Enhancement of glucocorticoid receptor transcriptional activity by cb1 cannabinoid receptor signaling. Its role on memory consolidation of aversive experiences

GRANJA GALEANO G; ZORRILLA ZUBILETE M; ZAPPIA C D; MONCZOR F; FRANCHI A; DOMINGUEZ RUBIO AP; FITZSIMONS C

San Pablo

Congreso; 10th Summer School On Medicines - Medicines: From Target to Market; 2018

Sao Paulo School of Advanced Science initiative (FAPESP, the São Paulo Research Foundation)

The cannabinoid receptor type 1 (CB1) and the glucocorticoid receptor(GR) are coexpressedin several brain areas involved in learning and memory, including thehippocampus, an area involved in spatial and episodic memory. Glucocorticoidsmediate the behavioral consequences of stress, such as memory consolidationassociated with emotionally arousing events. The downstream immediate-earlygene Egr1 is a GR-responsive gene involved in memory consolidation. It has beensuggested that CB1 signaling modulates GR-mediated transcriptional activity.Here, we studied the effect of CB1 signaling on GR-mediated transcriptionalactivity related to memory consolidation of aversive events