CHRONIC INTAKE OF Eruca vesicaria LEAVES EXTRACTS ALTERATES METABOLIC PROFILE AND INTESTINAL EFFLUX TRANSPORTERS ACTIVITY IN RATS.

CARBALLO, MARTA ANA; ROMA, MARTÍN IGNACIO; PERONI, ROXANA NOEMÍ; SCHIARITI LAMPROPULOS, VICTORIA E; LÓPEZ NIGRO, MARCELA MABEL

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

CHRONIC INTAKE OF ErucavesicariaLEAVES EXTRACTS ALTERATES METABOLIC PROFILE AND INTESTINAL EFFLUX TRANSPORTERSACTIVITY IN RATSIncreasing evidence implicates dietary factors in the progression of diseases, including cancer, diabetes and obesity. Diet also regulates ABC transporter expression and function impacting on drug elimination.The goal of the present study was to evaluate the activity of intestinal ABC transporters and metabolic profile after chronic intake of Erucavesicarialeaves (arugulacommercial variety).Adult male and female Sprague Dawley rats (20 weeks, n = 21) received an oral dose of E. vesicarialeaves juice representing human average intake (2g/kg), a methanol extract or saline solution three times a weekduring 4 weeks. Serosal to mucosal transport of substrates by MRP2, P-gp and BCRP was measured in everted sacs of proximal jejunum, distal jejunum and ileum, respectively. Glycaemia, triglycerides and cholesterol were determined.Juice intake decreasedMRP2-mediated efflux of doxorubicin in males (p