ININFA   02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Psychostimulant-mediated Effects on Medial Prefrontal Cortex: The Good and Bad Side of Dopamine
Autor/es:
V. BISAGNO
Lugar:
Columbia
Reunión:
Seminario; PHARMACOLOGY, PHYSIOLOGY & NEUROSCIENCE SEMINAR; 2015
Institución organizadora:
University of South Carolina, School of Medicine
Resumen:
The prefrontal cortex (PFC) has an essential role in cognition, emotion and reward. The PFC roles that are most pertinent to addiction include self-control, salience attribution and maintenance of motivational arousal. Indeed, dysfunctions in the PFC synaptic circuits are thought to be responsible for the loss of control over drug taking that characterizes addicted individuals. Repeated exposure to psychostimulants that increase dopamine neurotransmission, causes abnormal changes in neurotransmitter activity and neuronal plasticity in different areas of the PFC that mediate cognition and motivation. I will discuss these neural deficits related to changes in the PFC glutamatergic transmission observed both in humans and animal models.