Experiencing depression: choose your model

SILVIA WIKINSKI

Buenos Aires

Workshop; Desarrollo de modelos experimentales como un desafío permanente en Neurociencia; 2013

International Brain Organization/Sociedad Argentina de Neurociencias

Experiencing depression: choose your modelAccording to World Health Organization, depression is one of the most prevalent diseases in contemporaryworld. Therapeutic tools have prove to be effective in a significant proportion of patients, but almost 30% ofpeople suffering this disorder fail to respond to an adequate dose of antidepressants given for enough time. Therefore, a better knowledge of the physiopathogeny of depression and the identification of new biological targets remain a relevant objective of scientific research.Several models have been developed to study depression and to predict the potential antidepressant effect of drugs. In order to give guidelines for the selection of the most appropriate model for each experimental question, construct, face and predictive validities for the following behavioral procedures will be discussed: learned helplessness, chronic mild stress, social defeat, forced swimming test, restraint stress aint stress and prenatal exposure to stress. Reliability, cost-effectivity and reproducibility will be also analyzed.