ININFA   02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
New neuroprotective role of modafinil against methamphetamine acute toxic effects in mice.
Autor/es:
RAINERI M; GOITIA B; TARAVINI I R E; PESKIN V; GIORGERI S; URBANO FJ; BISAGNO V
Lugar:
Washington DC, USA, Nov 12-16, 2011
Reunión:
Congreso; 41th Society for Neuroscience Annual Meeting; 2011
Institución organizadora:
Society for Neuroscience
Resumen:
Modafinil (MOD) is an antinarcoleptic drug that is also being used off-label to treat psychostimulant addiction. Methamphetamine (METH) intake produces deleterious effects on brain function. The objective of the present study was to explore the neuroprotective role of MOD on METH neurotoxic effects. Mice were treated either with a METH single i.p. injection (2 or 7 mg/kg) or with a binge dosing protocol of METH (3 i.p. injections of 7mg/kg, 3 h apart) co-administrated with MOD (2 injections of 180 or 2 injections of 90 mg/kg, i.p., 1 h before first and third METH injection). Acute METH (7 mg/kg) administration induced hyperlocomotion (p