Neuroprotective properties of modafinil on methamphetamine-induced glial activation in mouse striatum

RAINERI M; GOITIA B; PESKIN V; GARCIA-RILL E; URBANO FJ; BISAGNO V

Huerta Grande, Cordoba

Congreso; XXVI Congreso Anual de la Sociedad Argentina de Investigacion en Neurociencia; 2011

Sociedad Argentina de Investigación en Neurociencia

Modafinil (MOD) is a stimulant used as a cognitive enhancer and is also prescribed to treat psychostimulant addiction. Methamphetamine (METH) intake produces deleterious effects in brain areas. In order to determine if MOD was able to counteract METH-induced glial activation, mice were treated with a METH "binge" protocol (4x5mg/kg, i.p., 2h apart) co-administrated with MOD (2x90mg/kg, i.p., 1h before 1st and 4th METH injections). After two days, METH treated group exhibited striatal reactive microgliosis and enhanced GFAP immunostaining but normal levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT). When METH was co-administered with MOD, glial activation values and TH and DAT levels were similar to those found in saline/MOD groups (p