INVOLVEMENT OF GABAB RECEPTORS IN THE CONTROL OF THE ANALGESIC RESPONSE OF MORPHINE USING A MODEL OF NEUROPATHIC PAIN IN MALE AND FEMALE BALB/C MICE.

PEREZ, VIRGINIA ; BALERIO, GRACIELA; VILLALOBOS VASQUEZ, JESUS

Mar del Plata

Congreso; Reunión Anual de Sociedades de Biociencias. LXVIII SAIC. XXV SAB. LV AAFE. VIII AACYTAL; 2023

SAIC

Neuropathic pain (NP) is a type of chronic pain that affects between 7-10% of the world population and continues without effective treatments. It has been suggested that the efficacy of combining pharmacological treatments lies in using analgesics that have different mechanisms of action. In previous studies of our laboratory, a GABAergic-opioid interaction was evidenced in a pain model. In this line, baclofen (BAC, GABAB agonist) was able to increase the antinociceptive effect of morphine (MOR) in the hot plate. On the other hand, it has been reported that the nerve injury that causes NP induces changes in the expression of brain derived neurotrophic factor (BDNF) in different brain areas related to pain. BDNF is a potential biomarker for NP because it promotes neuronal growth, maintenance, survival, and neurogenesis.The aims of the present study was to evaluate the participation of GABAB receptors in a model of neuropathic pain in mice of both sexes from a pharmacological approach. In addition, we analysed the expression of BDNF in areas related with pain.The behavioral results showed that MOR was able to reduce the NP in males and females (p < 0.05,0.001, respectively), while BAC increased this effect only in males (p