ININFA   02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
capítulos de libros
Título:
Mechanisms of GABA-A and GABA-B receptor gene expression
Autor/es:
DAVID FARB,; JANINE STEIGER,; MARIA CLARA GRAVIELLE; STELLA MARTIN,; TERRELL GIBBS,; SHELLEY RUSSEK,
Libro:
The GABA receptor
Editorial:
The Humana Press
Referencias:
Lugar: New York; Año: 2007; p. 1 - 1
Resumen:
g-Aminobutyric acid (GABA) is the primary inhibitory transmitter in the
adult nervous system and can activate three classes of receptors: metabotropic
type A GABA (GABAA), metabotropic type B GABA (GABAB), and
metabotropic type C GABA (GABAC) (for review see refs. 13). The ligandgated
GABAA receptor (GABAA R) is a pentameric complex assembled from
eight subunit families defined by amino acid (aa) sequence homology: á16,
adult nervous system and can activate three classes of receptors: metabotropic
type A GABA (GABAA), metabotropic type B GABA (GABAB), and
metabotropic type C GABA (GABAC) (for review see refs. 13). The ligandgated
GABAA receptor (GABAA R) is a pentameric complex assembled from
eight subunit families defined by amino acid (aa) sequence homology: á16,
metabotropic type C GABA (GABAC) (for review see refs. 13). The ligandgated
GABAA receptor (GABAA R) is a pentameric complex assembled from
eight subunit families defined by amino acid (aa) sequence homology: á16,
GABAA receptor (GABAA R) is a pentameric complex assembled from
eight subunit families defined by amino acid (aa) sequence homology: á16,
eight subunit families defined by amino acid (aa) sequence homology: á16,
â13, ã13, ä, å, ð, è, and ñ13. With the availability of powerful molecular
tools, the cloning of GABAA Rs led to the discovery that each subunit is
encoded by a distinct gene and most genes are organized in â-á-á-ã and â-á-13, ã13, ä, å, ð, è, and ñ13. With the availability of powerful molecular
tools, the cloning of GABAA Rs led to the discovery that each subunit is
encoded by a distinct gene and most genes are organized in â-á-á-ã and â-á-A Rs led to the discovery that each subunit is
encoded by a distinct gene and most genes are organized in â-á-á-ã and â-á-â-á-á-ã and â-á-
ã gene clusters on different chromosomes (4,5). Alternative splicing and alternative
promoters generate additional heterogeneity in GABAA-R subunit
variants that may allow for the assembly of thousands of possible pentameric
combinations. In contrast, the metabotropic GABAB R is made up of two distinct
subunits GABABR1 and GABABR2. It is now clear that the most abundant
GABABR1 isoforms (GABABR1a and GABABR1b) are produced by
alternative promoters in the GABABR1 gene (6), and there is no evidence for
GABAB2 variants (7).gene clusters on different chromosomes (4,5). Alternative splicing and alternative
promoters generate additional heterogeneity in GABAA-R subunit
variants that may allow for the assembly of thousands of possible pentameric
combinations. In contrast, the metabotropic GABAB R is made up of two distinct
subunits GABABR1 and GABABR2. It is now clear that the most abundant
GABABR1 isoforms (GABABR1a and GABABR1b) are produced by
alternative promoters in the GABABR1 gene (6), and there is no evidence for
GABAB2 variants (7).A-R subunit
variants that may allow for the assembly of thousands of possible pentameric
combinations. In contrast, the metabotropic GABAB R is made up of two distinct
subunits GABABR1 and GABABR2. It is now clear that the most abundant
GABABR1 isoforms (GABABR1a and GABABR1b) are produced by
alternative promoters in the GABABR1 gene (6), and there is no evidence for
GABAB2 variants (7).B R is made up of two distinct
subunits GABABR1 and GABABR2. It is now clear that the most abundant
GABABR1 isoforms (GABABR1a and GABABR1b) are produced by
alternative promoters in the GABABR1 gene (6), and there is no evidence for
GABAB2 variants (7).BR1 and GABABR2. It is now clear that the most abundant
GABABR1 isoforms (GABABR1a and GABABR1b) are produced by
alternative promoters in the GABABR1 gene (6), and there is no evidence for
GABAB2 variants (7).BR1 isoforms (GABABR1a and GABABR1b) are produced by
alternative promoters in the GABABR1 gene (6), and there is no evidence for
GABAB2 variants (7).GABABR1 gene (6), and there is no evidence for
GABAB2 variants (7).B2 variants (7).