ININFA   02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
Endogenous lysophosphatidic acid participates in vascularization and decidualization at the maternal-fetal interface in the rat
Autor/es:
JIMENA BELTRAME; GANNA DMYTRENKO; DAVIO CARLOS; MARIA LAURA RIBEIRO; ELSA ZOTTA ; MARIA SALES ; SILVINA PEREZ MARTINEZ; MICAELA SORDELLI; GOMEZ NATALIA; SANDRA BLOIS; FRANCHI ANA MARIA
Revista:
REPRODUCTION FERTILITY AND DEVELOPMENT
Editorial:
CSIRO PUBLISHING
Referencias:
Lugar: Collingwood; Año: 2017
ISSN:
1031-3613
Resumen:
Lysophosphatidic acid (LPA) influences several female reproductive functions through G protein-coupled receptors. LPA contributes to embryo implantation via lysophosphatidic type 3 receptor (LPA3). In this study, we investigated the participation of endogenous LPA signaling through LPA3 in vascularization and decidualization, two crucial events at the maternal-fetal interface. Pregnant rats were treated with diacylglycerol pyrophosphate (DGPP), a highly selective antagonist of LPA3, in day 5 of gestation. DGPP treatment produced aberrant embryo spacing and increased embryo resorption. Also, LPA3 antagonist decreased the cross sectional length of the uterine and arcuate arteries and induced histological anomalies in the decidua and placentas. Marked hemorrhagic processes, infiltration of immune cells and tissue disorganization were observed in the decidual and placental tissues from resorpted sites. The mRNA expression of interleukin 10 (Il-10), vascular endothelial growth factor (Vegf-a) and vascular endothelial growth factor receptor 1 (Vegf-r1), three vascularization markers, was reduced in resorpted sites from day 8. Our results show that the disruption of endogenous LPA signaling by blocking LPA3 modified the development of uterine vessels with consequences in the formation of the decidua and placenta and in the growth of the embryos.