ININFA 02677
INSTITUTO DE INVESTIGACIONES FARMACOLOGICAS
Unidad Ejecutora - UE
artículos
Título:
Pedunculopontine arousal system physiology- Implications for insomnia
Autor/es:
E. GARCIA-RILL; B. N. LUSTER; S. MAHAFFEY; V. BISAGNO; F. J. URBANO
Revista:
Sleep Science
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2015 p. 92 - 99
ISSN:
1984-0063
Resumen:
We consideri nsomnia a disorder of waking rather than a disorder of sleep.Thisreview examines the role of the reticular activating system,especially the pedunculopontine nucleus, in the symptoms of insomnia,mainly representing a noveractive waking drive. We determined that high frequency activity during waking and REM sleepi s controlled by two differentintracellularpathways and channel types in PPNcells.We found three different PPNcell types that haveoneor both channelsandmaybeactiveduringwaking only, REMsleeponly,orboth.These discoveries poin tt o a specific mechanism and novel therapeutic avenues for insomnia.
