Amyloid-β induces endothelial endoplasmic reticulum stress in association with blood-brain barrier disruption in experimental models of Alzheimer?s disease.

JESSICA PRESA; AMAL GREGOSA; CARLOS POMILIO; MELISA BENTIVEGNA; FLAVIA SARAVIA; ANGELES VINUESA; JUAN BEAUQUIS

Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2020

Alzheimer?s disease (AD) is the leading cause of dementia. Among other histopathologicalhallmarks, it is characterized by the abnormal accumulation of Amyloid-β (Aβ) peptides.Vascular alterations and blood-brain barrier disruption are also evidenced in AD patients,in close association with perivascular amyloid deposits, which are composed mainly of Aβ1-40. In this study we characterized the progression of vascular alterations in thehippocampus of PDAPP-J20 mice, a validated transgenic model for AD. We found asignificant increment in morphological alterations in vessels from AD mice compared toage-matched controls (p