Alzheimer?s Disease as a metabolic pathology: Inflammation and insulin resistance in a mouse model of AD. In vivo and in vitro approaches.

MELISA BENTIVEGNA; CARLOS POMILIO; JUAN BEAUQUIS; ANGELES VINUESA; FLAVIA SARAVIA; AMAL GREGOSA; JESSICA PRESA

Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2020

Sociedad Argentina de Investigación Clínica

Insulin resistance and chronic inflammation are frequently associated with the developmentof cognitive disorders and neurodegenerative diseases such as Alzheimer's disease (AD).However, it is not yet clear whether there is a causal link between these two factors, andwhich one appears earlier in the pathology. Our objective was to study metabolic parametersand inflammation in a possible brain insulin resistance context in a transgenic model of AD,the PDAPP-J20 mouse at the age of 8 months. We hypothesized that an inflammatoryenvironment could trigger insulin resistance in the brain, neurodegeneration and cognitiveimpairment. We found lower glycemic levels and altered phosphorylation levels of AKTmeasured by Western Blot -an indicator of the insulin signaling status- in the hippocampus oftransgenic mice compared with control mice (p