Resveratrol impairs cellular mechanisms associated with endometriosis development

GF MERESMAN; AG RICCI; S VALLA; RI BARAÑAO; D MADANES; M GÖTTE

Congreso; Reunión Anual de Sociedades de BioCiencias; 2020

SAIC

Endometriosis (EDT) is a benign gynecological disease with no available effective treatment due to its adverse side effects. Resveratrol (RES) is a natural polyphenol with well-known anticarcinogenic properties found abundantly in grapes, peanuts, and berries. We and others have shown its inhibitory effect on EDT development but its molecular mechanism is still unknown. The aim of this study was to evaluate the effect of RES (50-100µM) on the proliferation, migration and apoptosis of endometriotic epithelial cell line 12Z and endometrial stromal cell line St-T1b. We also studied its effect on gene expression related to cell migration and angiogenesis, and on the maintenance of stem cell pluripotency in both cell lines and in primary endometrial epithelial cell cultures (EEC). RES significantly decreased cell viability after 48h in both concentrations and both cell lines (p