IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Long Term Exposure to an Enriched Environment Induces Hippocampal Changes and Reduces Soluble Abeta Levels in a Transgenic Mouse Model of Alzheimer’s Disease (AD)
Autor/es:
BEAUQUIS J; GALVÁN V; ROIG P; DE NICOLA AF; SARAVIA F
Lugar:
Huerta Grande, Córdoba, Argentina
Reunión:
Congreso; II Reunión Conjunta de Neurociencias; 2010
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias y Taller Argentino de Neurociencias
Resumen:
Our aim was to explore the effects of environmental enrichment (EE) on the neurodegenerative process in an animal model of AD. Female transgenic mice (Tg, PDAPP-J20) carrying the Swe and Ind APP mutations and their non-transgenic siblings (NTg) were housed in EE or in standard conditions (SC) for 3 months (5 to 8 months of life). Soluble AB 1-40 and 1-42 brain levels were reduced in Tg in EE compared with Tg in SC. No differences were found in the number of AB plaques in the hippocampus. In situ hybridization for BDNF mRNA showed an increase in the dentate gyrus (DG) of Tg in EE compared with Tg in SC. Cell proliferation rate (Ki67 labeling) in the DG was significantly lower in Tg, with no effect of EE. Tg mice showed a decrease in the number of doublecortin+ cells in the DG. Survival of newborn BrdU+ cells (BrdU injected 21 days before euthanasia) showed an increase in both Tg and NTg with EE. Ratio of BrdU+NeuN+/BrdU+ cells was calculated, finding a decrease in Tg mice in SC and an increase with EE. Our results indicate that survival of hippocampal neuronal progenitors is promoted by EE in mice that model AD, correlating with increased levels of BDNF and lower levels of soluble AB. This might suggest an important role for social and sensorial stimuli in the pathogenesis of AD.