Effects of systemic administration of fluoxetine and tianeptine on an operant conditioning task in rats

FRICK, LR; RAPANELLI M; ZANUTTO, BS

Huerta Grande, Cordoba, Argentina

Taller; IIRCN: XXV Reunion Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN) y XII Taller Argentino de Neurociencias (TAN).; 2010

Sociedad Argentina de Investigacion en Neurociencias y Taller Argentino de Neurociencias

The medial Prefrontal Cortex (mPFC) is one of the brain structures that controls reward-directed behaviors. The mPFC is innervated by serotonergic axons and express serotonin (5-HT) receptors. Therefore, the serotonergic circuit comprising the mPFC could be involved in the learning of reward-dependent tasks. We studied the effects of systemic administration of Fluoxetine, a selective 5-HT reuptake inhibitor, and Tianeptine, a selective 5-HT reuptake enhancer, on the performance in a operant conditioning task. Adult Long Evans rats were trained in five sessions (25 trials each). Fluoxetine reduced the number of correct responses in the second and third session (p