Reproductive behavior in GABAB1KO adult male mice.

DI GIORGIO NP ; LIBERTUN C; SURKIN PN; REPETTO E; LUX-LANTOS VAR; BIZZOZZERO HIRIART M; BETTLER B

Modalidad virtual

Congreso; IV Reunión Conjunta de Sociedades de Biología de la República Argentina; 2020

Kiss1 neurons/cells co-express GABAB receptors (GABABR) and GABA is an important regulator of their physiology. Kiss1 expression is a key factor in the control of reproduction, sexual behavior and anxiety. Recently, we found Kiss1 overexpression in male mice lacking GABABR (KO) in the medial amygdala (MeA) and the basal nucleus of the stria terminalis (BNST), areas associated with sexual behavior and anxiety. Therefore, we studied the sexual behavior of KO and WT male mice in the presence of a receptive female. KO males developed less mounts during the first half hour of the encounter (Chi square test, p