IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A theory about a role of the hyper direct pathway in pattern expression by
Autor/es:
IVAN JOURDAN, PABLO BARTTFELD, B. SILVANO ZANUTTO.
Lugar:
Buenos Aires
Reunión:
Congreso; 32nd Annual International Conference of the IEEE EMBS; 2010
Institución organizadora:
IEEE
Resumen:
AbstractThe Basal Ganglia (BG) are a group of nuclei,
in the brain of mammalians and other vertebrates, strongly
connected with the cerebral cortex, thalamus and other brain
areas. The BG are associated with several brain functions
including learning and motor control. When there is cortical
activation, there is a strong synchronization between BG and
cortex, i.e. when a given task is being executed or in the case of
Parkinson disease[1], [2]. If we consider the internal segment of
the Globus Pallidus (GPi) there is synchronism between GPicortex
at frequencies as low as 3Hz to as high as 85Hz [1], [3].
In the other hand, in a delta sleep or in an anesthetized case,
a very low frequency correlation is observed (1-10 Hz), but no
high frequency correlation between GPi-cortex [1], [2], [3]. It is
unknown why this decorrelation happens. But It is agreement
that when there is no pattern to select, like in delta sleep or
with an anesthetized model, the BG network would maintain
the GPi and cortex decorrelated at high frequencies. Many
thalamus-BG and thalamus-BG-cortex loops are modulators of
the BG activity. Particularly there exists an anatomic thalamus-
BG loop, formed by GPi, intralaminar thalamic nuclei (IL)
and Subthalamic Nucleus (STN) [4]. Using a computational
model, based on an Integrate and Fire neural network, we
analyzed the IL nucleus as a modulator of the so-called hyper
direct pathway. Our results show that, in an anesthetic case,
this thalamic path could be relevant to allow a high frequency
decorrelated state between the GPi and cortex.The Basal Ganglia (BG) are a group of nuclei,
in the brain of mammalians and other vertebrates, strongly
connected with the cerebral cortex, thalamus and other brain
areas. The BG are associated with several brain functions
including learning and motor control. When there is cortical
activation, there is a strong synchronization between BG and
cortex, i.e. when a given task is being executed or in the case of
Parkinson disease[1], [2]. If we consider the internal segment of
the Globus Pallidus (GPi) there is synchronism between GPicortex
at frequencies as low as 3Hz to as high as 85Hz [1], [3].
In the other hand, in a delta sleep or in an anesthetized case,
a very low frequency correlation is observed (1-10 Hz), but no
high frequency correlation between GPi-cortex [1], [2], [3]. It is
unknown why this decorrelation happens. But It is agreement
that when there is no pattern to select, like in delta sleep or
with an anesthetized model, the BG network would maintain
the GPi and cortex decorrelated at high frequencies. Many
thalamus-BG and thalamus-BG-cortex loops are modulators of
the BG activity. Particularly there exists an anatomic thalamus-
BG loop, formed by GPi, intralaminar thalamic nuclei (IL)
and Subthalamic Nucleus (STN) [4]. Using a computational
model, based on an Integrate and Fire neural network, we
analyzed the IL nucleus as a modulator of the so-called hyper
direct pathway. Our results show that, in an anesthetic case,
this thalamic path could be relevant to allow a high frequency
decorrelated state between the GPi and cortex.