Neuroprotective effects of oxalis erythrorhiza in diabetes mellitus.

MAGRINI-HUAMAN, R.N.; COIRINI, H.; KRUSE, M. S.; FERESIN, G. E.; REY, M.; TAPIA, A.

Mar del Plata

Congreso; Reunión Anual de Biociencia 2019 - SAIC-SAFE-SAB-SAP-NANOMEDar-AACyTAL-HSC; 2019

Sociedad Argentina de Investigación Clínica

In the last decades, the exploration ofphytomedicine became an important issue to find newtherapeutic treatments. In the Cuyo region (Argentine), Oxaliserythrorhiza Gillies ex Hooker et Arnott (Oxalidaceae; Oe) is popularly consumed as a ?medicinal plant? for hepatic and heartcomplains even when these effects lack scientific support.Recently, chemical characterization of aereal parts of Oerevealed the presence of compounds with potentialantidiabetogenic properties. Otherwise, the diabetes mellitusrepresents an important health concern, as involved chronichyperglycemia, oxidative stress state and neurodegenerativechanges. Previously, we showed that Oe decoction improves theincrease in neurofilaments (NF200) observed in thehypothalamus of rats with experimental diabetes. In this work,adult male rats, controls (C, i.p. veh) or diabetics (D, i.p. STZ30mg/Kg) drunk Oe decoctions at 5 % (COe5/DOe5), 10 %(COe10/DOe10), or water (CW/DW) by 4 weeks. nNOS andNF200 expressions levels were studied by WB in hippocampusand cerebral cortex. Compared to CW, DW presented raises innNOS and NF200 expressions in hippocampus (32.50 and 33.50% respectively; p