NATIVE PLANTS AND NEUROPROTECTIVE EFFECTS IN DIABETES MELLITUS

REY, M.; MAGRINI-HUAMAN, R.N.; TAPIA, A.; COIRINI, H.; KRUSE, M.S.; FERESIN, G.E.

Buenos Aires

Congreso; XX ANNUAL MEETING OF THE ARGENTINEAN BIOLOGY SOCIETY; 2019

Sociedad Argentina de Biología / Sociedad Uruguaya de Biociencias

In Cuyo region (Argentine) Tessaria absinthioides (Ta) and Oxalis erythrorhiza (Oe) are popularly consumed to regulate glucose (Glu) and cholesterol (Chol) levels, lacking of scientific support. Several works indicate that 85% of world population uses ?medicinal plants? to treat its health. Diabetes mellitus courses chronic hyperglycemia, oxidative stress state and neurodegenerative changes. Previously we had shown effects of Ta and Oe decoctions on LXRs expression in hypothalamus. In this work, adult male rats (SD), controls (C,i.p.veh) or diabetics (D,i.p.STZ30mg/Kg) drunk 10%W/V decoctions of Ta (CTa/DTa), Oe (COe/DOe) or water (CW/DW) by 4 weeks. Glu, Chol and triglycerides (Tg) levels were measured on blood samples by commercial kits. The hypothalamic neural NOS (nNOS) and Neurofilaments200 (NF200, 3 different bands) expression levels were studied by WB. Compared to CW, DW, DOe and DTa had higher levels of Glu (350%, 200% and 200%; p