THE THYROID STATUS REGULATES TRIPLE NEGATIVE BREAST CANCER (TNBC) GROWTH AND METASTASIS THROUGH THE MODULATION OF MESENCHYMAL STROMAL CELL (MSC) MIGRATION AND ANTITUMOR IMMUNE RESPONSE

GUTIERREZ L; DÍAZ FLAQUÉ, MARÍA CELESTE; CREMASCHI, GRACIELA A.; STERLE, HELENA ANDREA; PAULAZO, M.A.; ROSEMBLIT, CINTHIA; HILDEBRANDT, XIMENA ; CAYROL, FLORENCIA; BOLONTRADE, M

Mar del Plata

Congreso; Reunion conjunta SAIC SAI SAFIS; 2018

The association between thyroid disease and breast cancer risk remains unclear. Our aim was to evaluate the effect of thyroid status on TNBC development. For this, Balb/c mice were orthotopically inoculated with 4T1 cells after the treatment with thyroxine (12mg/l) for 30 days or propylthiouracil (500mg/l) for 15 days in the drinking water to obtain hyperthyroid (hyper) or hypothyroid (hypo) mice, respectively. An increased tumor growth rate, that became evident at day 21 post-inoculation (p.i.), was seen in hyper mice compared to controls (p