NF200 EXPRESSION IN RATS WITH EXPERIMENTAL DIABETES AFTER NATIVE PLANTS DECOCCTIONS CONSUMPTIONNF200 EXPRESSION IN RATS WITH EXPERIMENTAL DIABETES AFTER NATIVE PLANTS DECOCTIONS CONSUMPTION

KRUSE, M. S.; FERESIN, G. E,; MAGRINI-HUAMA;N, R.N; COIRINI, H.; REY, M.; TAPIA, A.

Mar del Plata

Congreso; LXIII Reunion Anual de la Sociedad de Investigacion Clinica; 2018

Sociedad Argentina de Investigacion Clínica

Numerous studies indicate that 85% of world population uses ?medicinal plants? to improve its health. Oxalis erythrorhiza(Oe) and Tessaria absinthioides(Ta) growth in Cuyo region(Argentine), and are popularly consumed to regulate the glucose and cholesterol levels, even when it does not exist a scientific support. Diabetes mellitus represents a major problem for health systems. These patients have a chronic hyperglycemia, an oxidative stress state (through the Oxide Nitric Sintase (NOS) induction), and can also develop degenerative changes in neurons and glial cells. Thus the search of new alternative therapies remains in force. We had previously, shown effects of Oe and Ta decoctions(10%W/V) on metabolism and hypothalamic LXRs expression. In this study, 42 days old male rats(SD), diabetics(Ed, i.p.STZ30mg/Kg) or controls(C,i.p.vehicle) received (5% W/V) decoctions of Oe(EdOe/COe) or Ta(EdTa/CTa), or water(EdW/CW) as drink for 4 weeks. Glucose, cholesterol and triglycerides were measured on blood samples by colorimetric kits. Hypothalamic neural NOS(nNOS) and Neurofilaments 200(200 kDa(NF200); 160kDa(NF160) and 68kDa(NF68)) expression levels were evaluated by WB. Glucose levels in EdW were significantly higher than CW(300%;p