EARLY EXPOSURE TO A HIGH FAT DIET PROMOTES COGNITIVE IMPAIRMENT, NEUROINFLAMMATION AND DECREASED HIPPOCAMPAL PLASTICITY. POSSIBLE IMPLICATION OF MICROGLIA- DERIVED EXOSOME- LIKE EXTRACELLULAR VESICLES

CALFA, GASTÓN; BONAVENTURA, MARÍA MARTA; PRESA, JESSICA; SARAVIA, FLAVIA; BENTIVEGNA, MELISA; VINUESA, ANGELES; POMILIO, CARLOS; FILIPELLO, FABIA; GREGOSA, AMAL; LUX-LANTOS, VICTORIA; MATTEOLI, MICHELA; BEAUQUIS JUAN

Mar del Plata

Congreso; Reunion Anual de la Sociedad Argentina de Investigacion Clinica; 2018

SAIC

Western dietary habits including high fat-industrialized foods are increasinglyrepresented in juvenile populations and constitute one ofthe factors that affect brain health, potentially leading to long lastingeffects. Adolescence, characterized by brain maturation and behavioralchanges, is particularly vulnerable to the environment. Hence,our aim was to study the impact of an early exposure to a high fatdiet (HFD) on mouse hippocampal plasticity and cognition. To thatend, C57BL/6J male mice were exposed to HFD for 6 weeks sinceweaning. Glycemia and seric proinflammatory IL1β were higherin HFD mice (p