Novel pathophysiological role of PDGF-B in OHSS, an ovarian syndrome with vascular hyperpermeability and ascites

SCOTTI, LEOPOLDINA; TESONE, MARTA; PARBORELL, FERNANDA; OUBIÑA, GONZALO; BUSSO, DOLORES; OUBIÑA, GONZALO; BUSSO, DOLORES; PASCUALI, NATALIA; DE ZÚÑIGA, IGNACIO; ABRAMOVICH, DALHIA; PASCUALI, NATALIA; DE ZÚÑIGA, IGNACIO; ABRAMOVICH, DALHIA; SCOTTI, LEOPOLDINA; TESONE, MARTA; PARBORELL, FERNANDA

Helsinki

Congreso; International Vascular Biology Meeting; 2018

Ovarianhyperstimulation syndrome ( is an iatrogenic complication ofovulation induction and ovarian stimulation for assisted reproductive technology( and is characterised by rapid fluid shifts from the intravascular compartment tothe third space 1 2 Its prevalence is 5 10 of patients that undergo ART and it is apotentially life threatening condition in its severe form 3 Although the pathophysiology of the syndrome is not completely understood, and no specific therapyor prevention is available yet, it is known that an imbalance between pro and antiangiogenic factors present in follicular fluid ( induces high permeability and,therefore, the presence of ascites in these patients 4 6 However, few studies havedemonstrated the participation of angiogenic factors other than VEGF in OHSSdevelopmentPDGFligands are involved in vascular stability and permeability 7 10particularly through peri endothelial cell recruitment 11 Therefore we proposed thefollowing hypothesis a) Deregulation of PDGF is implicated in the OHSS pathogeny,therefore affecting blood vessels and contributing to the excessive vascularpermeability that leads to ascitis in OHSS patients