META-TYROSINE INHIBITS THE PROLIFERATION OF ESTABLISHED METASTASES IN A HUMAN MAMMARY ADENOCARCINOMA AND INDUCES APOPTOSIS IN TUMOR CELLS WITHOUT APPARENT TOXIC EFFECTS FOR THE ORGANISM

DANIELA MONTAGNA; MÓNICA VERMEULEN; ARIEL STRAZZA; GONZALO SEQUEIRA; PAULA CHIARELLA; JULIETA ALCAIN; RAÚL RUGGIERO

Buenos Aires

Congreso; Reunión conjunta de sociedades de biociencias; 2017

SAI

The development of new strategies to limit metastatic growth aftertumor removal is one of the greatest clinical challenges today. Inprevious work we have shown that meta-tyrosine (m-tyr), an isomerof tyrosine absent in normal proteins, is responsible, at least inpart, for the phenomenon of Concomitant Tumor Resistance (CR);in which a tumor-bearing host inhibits the growth of secondary tumorimplants. In this work we propose a deeper understanding of themolecular and antitumor mechanisms involved in CR as well as thestudy of the effectivity of its administration by the intraperitoneal (i.p)route. NOD scid gamma mice with a 41-day MDA-MB-231 humantumor received a daily i.p injection of 2.5 mg/mouse of m-tyr or saline(control) for 18 days. After the treatment all mice were sacrificedand lung metastases counted. At day 59 the number of metastases(Median [range]) was 10.0 [4-39] and 4.0 [0-14] for the control andm-tyr group respectively (p