4T1 AND LM3 MURINE BREAST TUMORS INDUCE SYSTEMIC ALTERATIONS OF THE B CELL COMPARTMENT

RABINOVICH GA; MORALES, ROSA; SARBIA N; TOSCANO MA; DALOTTO-MORENO T; MARTINEZ ALLO V; SALATINO M; GATTO, S; MANSELLE COCCO, M

Congreso; Second AACR International Conference TRANSLATIONAL CANCER MEDICINE; 2018

AACR

Anti-tumor immunity has been a matter of extensive research for several years, resulting in highly effective immunotherapies widely used against several types of cancer. While the roles of T cells and myeloid cells have been broadly studied, B cell function is still not thoroughly understood.In order to determine if the presence of malignant tumors has an impact over the B cell compartment, we analyzed by flow cytometry the frequency and number of the different B cell subsets in the bone marrow and spleen of BALB/cJ tumor-free mice and compared it to tumor-bearing mice of the same strain.To begin with, we found a dramatic reduction in the number of B220+ CD19+ B cells (p