BREAST CANCER SHAPES B CELL COMPARTMENT TOWARDS IMMATURE DEVELOPMENTAL STAGES

SALATINO M ; SARBIA N; RABINOVICH GA; TOSCANO MA; MANSELLE COCCO, M

Congreso; Reunión Conjunta de las Biociencias; 2017

Unlike T cells, that have been broadly studied in anti-tumor immunity, the role of B cells in cancer progression remains a matter of controversy. Using different murine tumor models (4T1, LM3 and CT26) we sought to understand how the B cell compartment is phenotypical and functionally shaped by the presence of tumors altering the host?s immune response. For this, we analyzed B cell ontogeny by determining the frequency and number of B cell subsets in the bone marrow and spleen of tumor-free and tumor-bearing mice. We found that mice with 4T1 and LM3 mammary tumors had a dramatic reduction in the number of bone marrow B cells B220+ CD19+ (p