Platelet-derived growth factor B (PDGFB) improves follicular development and ovarian angiogenesis in rar model of polycystic Ovary Syndrome

F. PARBORELL; G. IRUSTA; TESONE M; L SCOTTI; N PASCUALI; DI PIETRO, MARIANA

Rome

Congreso; 17 th World Congress of the Academy of Human Reproduction; 2017

Introduction: Alterations in ovarian angiogenesis are common features in Polycystic Ovary Syndrome (PCOS) patients; the most studied of these alterations is the increase in vascular endothelial growth factor (VEGF) production by ovarian cells. Platelet-derived growth factor B (PDGFB) and D (PDGFD) are decreased in follicular fluid of PCOS patients and in the ovaries of a rat model of PCOS. Hypothesis: Restoration of ovarian PDGFB levels can improve ovarian angiogenesis and follicular development in a rat model of PCOS. Objectives: In the present study, we aimed to analyze the effects of local administration of PDGFB on ovarian angiogenesis, follicular development and ovulation in a DHEA-induced PCOS rat model.Results: Ovarian PDGFB administration to PCOS rats partially restored follicular development, decreased the percentage of cysts, increased the percentage of corpora lutea, and decreased the production of anti-Müllerian hormone. In addition, PDGFB administration improved ovarian angiogenesis by reversing the increase in periendothelial cell area and restoring VEGF levels. Conclusion: This study demonstrates, for the first time, a beneficial effect of local PDGFB administration on luteal development and ovarian angiogenic factors in a rat model of PCOS. The results presented contribute to the knowledge of the ovarian mechanisms that lead to altered ovarian function in PCOS and provide new data for potential therapeutic strategies. Studies in women are needed to fully translate these findings to PCOS patients.