CHANGES IN OXIDATIVE STRESS MARKERS BY DIETARY SUPPLEMENTATION WITH NATURAL OILS

COIRINI, H.; REY, M.; FERESIN, G. E.; VEGA, M.C.; TAPIA, A. J.; MAGRINI-HUAMÁN, R.N.

CABA

Congreso; REUNION CONJUNTA DE SOCIEDADES DE BIOCIENCIAS (XIX REUNION ANUAL DE LA SAB); 2017

Uncontrolled maternal hyperglycemia during pregnancy produces an increase in oxidative stress causing alterations in the developing nervous system of the offspring. The aim of this work was to evaluate the effect of an early dietary supplementation with natural oils on the oxidative stress state at adulthood. Adult male Sprague-Dawley rats born from control mothers (CO) and mothers with experimental diabetes (DO; Streptozotocin, 30 mg/Kg iv.) were orally supplemented with corn oil (Mz; used as control) or with either extra virgin olive oil (Ol) or pistachio oil (Ps) from day 2 to 62 (8μl /15g). At 8 months old, oxidative markers like the activity of superoxide dismutase (SOD) and Malondialdehyde (MDA) concentrations were evaluated in plasma (P) and hypothalamus homogenates (HT). DO-Mz animals showed reduce SOD activity, and increased MDA respect CO-Mz animals in P and HT (SOD=48%,15%; MDA=20%; 92% respectively; p