Phospho S6 (pS6) expression and tumor localization in response to neoadjuvant chemotherapy in breast cancer

PERRONE MC, POLO ML, RODRÍGUEZ MJ, RIGGIO M, ENRICO D, BENES M, MAC DONNELL M, ZWENGER A AND NOVARO V.

Congreso; Reunión Conjunta de Sociedades de Biociencias, Buenos Aires, Argentina.; 2017

Neoadjuvant treatment benefits include in vivo assessment of tumor response to treatment as well as tumor reduction before surgery. In a recent study, we observed that neoadjuvant endocrine therapy in luminal breast cancer induced a reparative stromal reaction, including neovascularization, immune cells infiltration and carcinoma-associated fibroblasts that stain for phosphorylated S6 (pS6), a protein downstream PI3K/AKT/mTOR pathway. We also demonstrated that stromal levels of pS6 correlated with tumor shrinkage percentage after treatment (p