Role of protein kinases in the development of Tamoxifen and Palbociclib resistance in breast cancer

RODRIGUEZ M. JIMENA, POLO M. LAURA, PERRONE M. CECILIA, RIGGIO MARINA, ENRICO DIEGO, MARKS M. PAULA, VELLÓN LUCIANO, ALCOBER BOQUET LUCÍA, NOVARO VIRGINIA.

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias, Buenos Aires, Argentina.; 2017

Abstract: It is estimated that approximately 70% of breast tumors express hormone receptors for estrogen (ER) and progesterone (PR). Although ER antagonist tamoxifen has been successful for ER+ breast cancer treatment, a significant amount of these tumors eventually develop resistance. In order to study this phenomenon, we generated a tamoxifen-resistant cell line derived from the human breast cancer cell line T47D (T47D-TR), by long-term cell exposure to progressively increasing concentrations of tamoxifen. This resistant cell line showed an increase in basal activation of ER despite reduction in its expression levels (p