¨The activation of the immune system as a consequence of tissue remodeling after endocrine treatment may participate preventing tumor relapse¨

SEQUEIRA G; SAHORES A; DALOTTO-MORENO T; VANZULLI S; POLO M.L; RADISKY D; NOVARO V; LAMB C; SALATINO M; LANARI C.

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias, Buenos Aires, Argentina.; 2017

Tumors from the MPA-induced murine mammary carcinoma model are sensitive to antiprogestins and regress after mifepristone (MFP) treatment (Lanari et al., 2009). During this process there is a concurrence of different cell types into the tumor stroma (Vanzulli et al., 2002).We have recently generated a murine model using Nod-SCID-gamma (NSG) mice and Bone Marrow (BM) from BALB/c-GFP mice to obtain NSG/BM-GFP which allows us to study the role of the immune system in endocrine tumor regression. The goal of this study was 1) investigate if the immune system is involved in the antiprogestin induced tumor regression and 2- determine if MFP is able to generate a protective memory against a tumor re-challenge.