IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Hyperprolactinemia induced by selective disruption of dopamine type 2 receptors in pituitary lactotropes produces leptin insensitivity and altered gene expression in specific hypothalamic nuclei
Autor/es:
GUILLERMINA MARÍA LUQUE; MARÍA FELICITAS LÓPEZ VICCHI; DAVID GRATTAN; SHARON LADYMAN; DAMASIA BECU-VILLALOBOS; ANA MARÍA ORNSTEIN
Lugar:
Steamboat Springs
Reunión:
Congreso; Growth Hormone/Prolactin Family in Biology and Disease; 2017
Institución organizadora:
FASEB
Resumen:
The brain plays an essential role in maintaining energy homeostasis and substantial evidence indicates that neural circuits within the hypothalamus are paramount. In this context, we studied the hypothalamic neural circuits that control energy homeostasis in female mice that selectively lack dopamine type 2 receptors from pituitary lactotropes (lacDrd2KO). These mice have chronic hyperprolactinemia, increased food intake and body weight. We dissected the arcuate nucleus (ARN), the ventromedial hypothalamus (VMH), dorsomedial hypothalamus (DMH) and paraventricular nucleus (PVN), where prolactin could be potentially regulating metabolism, and evaluated mRNA levels of genes relevant to the central control of food intake and body weight. mRNA levels of Agrp were significantly increased in the ARN (p