Protective effects of exogenous testosterone in an animal model of motoneuron degeneration desease.

GARGIULO-MONACHELLI G; LIMA A.; GARAY L; DE NICOLA AF; LUX LANTOS V; MEYER M; GONZALEZ DENISELLE MC; GUENNOUN R; DI GIORGIO NP; LARA A

Buenos Aires

Simposio; Simposio: The role of glial cells in health and disease of the Nervous System: Clinical and Basic Science walking together; 2017

Wobbler (WR) mouse, is a useful animal model for human amyotrophic lateral sclerosis (ALS),it shows mitochondrial degeneration with increased levels of inflammatory mediators and astrogliosis in the spinal cord. It?s been described that some steroids such as progesterone favor mitochondrial function and neuroprotection, while others are deleterious. We know that testosterone (T) levels in male WRs are lower than male control animals in serum, spinal cord and brain (p