HYPERCOAGULABLE STATE AND RISK OF TROMBOSIS IN THE DOG WITH CUSHING?S DISEASE

VIDAL PN; CASTILLO VA; MICELI, DD

Ciudad Autónoma de Buenos Aires

Congreso; Reunión conjunta de sociedades de biociencias; 2017

Sociedad Argentina de Investigación Clínica

Hypercoagulable state is a situation of high morbidity and mortalityin the dog with Cushing?s Disease (EC). The most serious conditionis pulmonary thromboembolism which is a cause of death. D-dimer(DD), a degradation product of fibrin, is an indicator of thrombosis.The Von Willebrand Factor (FvW) and the inhibitor of plasminogenactivator-1 (PAI-1), are increased in plurimetabolic syndromes. Theobjective of this study was to evaluate whether the activity of AntithrombinIII (ATIII) and DD are useful as indicators of formation orpresence of thrombosis and to analyze the concentrations of FvWand PAI-1 in the dog with EC compared to a group of healthy dogs.We studied a total of 26 dogs with EC. To make the comparison12 of them were taken and then 12 dogs from the bioterior, as acontrol group. All patients underwent platelet counts, coagulationtimes (KPTT and prothrombin time (PT)), fibrinogen (F), ATIII expressedas ATIII activity (normal> 80%) and DD (positive> 200, DD+). FvW and PAI-1 were measured by ELISA. Proteinuria in relationto creatinine (PRC, normal value