The glycan-galectin axis modulates tumor development and immune response in a murine modelo f colitis-associated colorectal cáncer

CUTINE AM; MAZZEO C; GIROTTI MR; CAGNONI AJ; GATTO S; MAY M; MORALES R; MARIÑO KV; MAHMOUD Y; RABINOVICH GA

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Inflammatory Bowel Diseases (IBD) have been associated with an increase in the incidence of colorectal cancer (CRC), the third more frequent cancer worldwide. It has been previously reported that the intestinal inflammatory microenvironment favors neoplastic development, although the underlying molecular mechanisms are not yet completely understood. During the last decades, aberrant cell surface glycosylation has been considered an important hallmark of cancer and tumor progression. Glycosylation changes trigger different biological processes via interaction with glycan-binding proteins such as galectins (Gal). We aimed to study the effect of the inflammatory microenvironment on the galectin-glycan interactions and CRC progression.