IBYME   02675
INSTITUTO DE BIOLOGIA Y MEDICINA EXPERIMENTAL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Novel immunoregulatory roles for CRISP proteins within the epididymis
Autor/es:
CARVAJAL, GUILLERMO; BRUKMAN, NICOLÁS G.; WEIGEL MUÑOZ, MARIANA; BATTISTONE, MARÍA A.; LUSTIG, LIVIA; BRETON, SYLVIE; CUASNICÚ, PATRICIA S.; CARVAJAL, GUILLERMO; BRUKMAN, NICOLÁS G.; WEIGEL MUÑOZ, MARIANA; BATTISTONE, MARÍA A.; LUSTIG, LIVIA; BRETON, SYLVIE; CUASNICÚ, PATRICIA S.
Lugar:
Copenhague
Reunión:
Congreso; 11th International Congress of Andrology.; 2017
Resumen:
Epididymal proteins CRISP1 and CRISP4 associate with sperm during maturation and participate in fertilization. However, knockout (KO) mice for each of these molecules are fertile, suggesting compensatory mechanisms between these homologous proteins. To address this question, we generated CRISP1/CRISP4 double KO (DKO) mice and examined their phenotype. DKO males exhibited severe defects in fertility (p*